Table 1.
DNA methylation of CpGs in promoter sequences 2000 bp 5′-upstream of transcription start site (TSS).
| Gene | Protein | CpG island (s) | DNA methylation |
|---|---|---|---|
| CDKN2A | P16 | 4 (1a) | No |
| CDKN1A | P21 | 0 (1a) | Yes |
| TP53 | Tumor Protein P53 | 3 | No |
| RASSF1A | Ras Association Domain Family Member 1 | 1 (1a) | No |
| NEIL1 | Nei Like DNA glycosylase 1 | 3 | No |
| NEIL2 | Nei Like DNA glycosylase 2 | 1 (1a) | No |
| OGG1 | 8-oxoguanine DNA Glycosylase | 2 | Yes |
| APEX1 | Apurinic/Apyrim. Endodeoxyribonuclease 1 | 2 | Yes |
| POLB | DNA Polymerase Beta | 0 (1a) | Yes |
| UNG | Uracil DNA Glycosylase | 2 (1a) | Yes |
| IL18 | Interleukin 18 | 1 | Yes |
| DNMT3A | DNA methyltransferase 3A | 1 | Yes |
| MANF | Mesencephalic Astrocyte Deriv. Neurotro. Fact. | 1 | No |
| MAPT | Microtubule Associated Protein Tau | 1 | No |
** Methylation in exon 1.
a
CpG island in exon 1.