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Total collagen quantification shows regulation by collagen XII during development and in adult age. Total collagen in wild-type (WT) and Col12a1−/− corneas from different mice was analyzed in preadult postnatal day (P) 30 (A) and adult P90 (B) in WT and Col12a−/− male mice. P30 (WT n = 6, Col12a1−/− n = 10); P90 (both groups n = 5). ∗P < 0.05, ∗∗∗∗P < 0.0001.
