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Collagen XII regulates transforming growth factor-β responsive genes in the corneal stroma in vivo in corneas with epithelium. Serpine1 (A), Col1a1 (B), Col5a1 (C), and LOX (D) mRNA expression was down-regulated by collagen XII. ∗∗P < 0.01, ∗∗∗P < 0.001. WT, wild type.
