Table 2.
Metabolic Genes
| Gene symbol | Gene name | L1FLX alcohol diet vs ctrl diet (log2FC) | L1FLX alcohol diet vs ctrl diet (padj) | L1LKO alcohol diet vs ctrl diet (log2FC) | L1LKO alcohol diet vs ctrl diet (padj) |
|---|---|---|---|---|---|
| Metabolic regulator genes | |||||
| Sirt1 | Sirtuin 1 | −0.93 | 0.01 | −0.08 | 0.88 |
| Sirt3 | Sirtuin 3 | −1.32 | 0.02 | −0.90 | 0.001 |
| Lipid metabolism | |||||
| Lpin1 | Lipin 1 | −1.12 | 0.07 | −1.28 | 0.01 |
| Lpin2 | Lipin 2 | −0.31 | 0.75 | −0.90 | 0.008 |
| Lpin3 | Lipin 3 | 1.33 | 0.02 | 0.25 | 0.67 |
| Lpl | Lipoprotein lipase | 2.3 | 0.001 | 0.3 | 0.55 |
| Lipogenesis | |||||
| Srebf1 | Sterol regulatory element binding transcription factor 1 | −2.28 | 5.99−05 | −1.68 | 6.15−07 |
| Fasn | Fatty acid synthase | −1.78 | 0.05 | −0.64 | 0.32 |
| Scd1 | Stearoyl coenzyme A desaturase 1 | −1.89 | 0.03 | −0.54 | 0.48 |
| Fatty acid oxidation | |||||
| Ppara | Peroxisome proliferator activated receptor alpha | −1.19 | 0.01 | −0.98 | 0.04 |
| Acad8 | Acyl-coenzyme A dehydrogenase family member 8 | −0.65 | 0.03 | −0.29 | 0.36 |
| Cpt1a | Carnitine palmitoyltransferase 1a liver | −0.39 | 0.71 | −0.94 | 0.01 |
| Cd36 | CD36 antigen | −0.02 | 0.98 | 0.27 | 0.75 |
| Fgf21 | Fibroblast growth factor 21 | 0.7 | 0.60 | 2.0 | 5.92−06 |
| Alcohol metabolism | |||||
| Aldh1a1 | Aldehyde dehydrogenase family 1 subfamily A1 | −0.75 | 0.28 | 0.21 | 0.68 |
| Cyp2e1 | Cytochrome P450 family 2 subfamily e polypeptide 1 | −1.54 | 0.003 | −0.74 | 0.14 |
Differentially expressed metabolic genes in alcohol-diet–fed ZFP36L1-sufficient (L1FLX) and liver-specific ZFP36L1-deficient (L1LKO) mice and control diet–fed ZFP36L1-sufficient (L1FLX) and liver-specific ZFP36L1-deficient (L1LKO) mice are shown. Bold values depict significant differences.