Table 2.

Description of included studies.

References	Intervention	Change in care delivery	Process goal	Target patients	Setting	Theoritical framework
Fortin et al. (7)	Multifaceted intervention including nurse interview and, consultations with other professionals and individualized care plan.	Professionals were added to existing family medicine teams	To enhance patient self-management	3 or more chronic conditions	7 family medicine groups (FMGs) in Quebec, Canada	Patient Centered Clinical Method (17), Chronic Care Model (16), and Self-management support (18)
Stewart et al. (9)	Multifaceted patient-centered care including a nurse interview at home, a team meeting, a care plan and nurse follow-up	Professionals were added and the team meeting was added	To improve patient engagement in their care and to reduce emergency room visits	3 or more chronic conditions	9 team-based family practices familiar with the intervention in Toronto, Ontario, Canada	Patient Centered Clinical Method (17), Chronic Care Model (16), and Self-management support (18)
Salisbury et al. (6)	Two appointments with a nurse and a named responsible physician, a medication review by a pharmacist, and a collaborative health plan with the patient	Replacing disease-focused reviews of each health condition by a comprehensive 3D multidisciplinary review	To improve continuity, coordination, and efficiency of care	Patients with at least 3 types of chronic conditions	33 practices in England and Scotland	Patient Centered Clinical Method (17), and Chronic Care Model (16)
O'Toole et al. (12)	Professionally-led 6-week group self-management support program	Introducing educational and goal-setting components that included participant interaction and discussion	Self-management support aimed to have a specific focus on function and issues relevant to multimorbidity	2 or more chronic conditions	8 primary care teams in Eastern Ireland	Self-management support (18)
Kari et al. (13)	At-home patient interviews, an interprofessional team meetings (nurse, pharmacist and genral practitionner) to create a care plan	To include in-depth clinical medication and health reviews which are not present within the existing health system	To encourage patient active role in collaborative goal setting and empower them to live well with long-term conditions	Multimorbid patients with 7 or more prescribed medicines	Primary care settings in Tornio, Finland	People Centered Care Model (10), and Chronic Care Model (16)
Verdoorn et al. (14)	Clinical medication reviews (CMRs) with the availability of all clinical data and an extensive patient interview	A CMR review focused on personal goals which is not offered to all patients in usual care	Building on patients' health-related goals and preferences	Community-living multimorbid patients with 7 or more long-term medications	35 community pharmacies in the Netherlands	Patient Centered Approach in Clinical Medication Review (8)