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. 2022 Feb 24;13:809469. doi: 10.3389/fphar.2022.809469

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Copyright © 2022 Yao, Hao, Wen, Xiao, Wu, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HO-1 inducer and inhibitor affect the NK and MDSC in the spleen. (A) Bar plots showing the frequencies of Ly6C⁺NK, Ly6C⁻NK, and all NK cells in spleen (SP) CD45⁺ cells obtained from ApoE^-/- mice treated with hemin or SnPP or vehicle, respectively. (B) Dot plots (n = 24) showing the Pearson correlation coefficients for relationships between the concentrations of total (TCHO) or LDL cholesterol in peripheral blood and the frequencies of indicated NK cell subsets in the spleen. (C) Bar plots showing the frequencies of PMN-MDSCs, M-MDSCs, and all MDSCs in spleen CD45⁺ cells obtained from ApoE^-/- mice treated with hemin or SnPP or vehicle, respectively. (D) Dot plots (n = 24) showing the Pearson correlation coefficients for relationships between the concentrations of total (TCHO) or LDL cholesterol in peripheral blood and the frequencies of indicated MDSC subsets in the spleen. Bar graphs represent mean ± SD. Dots represent individual samples. n (control) = 8, n (hemin) = 6, n (SnPP) = 10. *p < 0.05, ***p < 0.001, ****p < 0.0001 (One-way ANOVA).