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. 2022 Feb;10(4):226. doi: 10.21037/atm-22-214

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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SNHG12 promotes the proliferation, migration, and invasion of melanoma cells. SNHG12 was overexpressed in A375 cells and SNHG12 was silenced in CHL-1 cells. (A,B) The CCK-8 experiment and (C,D) EdU experiment (red: EdU, blue: DAPI, purple: merge; 100×) were conducted to study the influence of SNHG12 on cell proliferation, (E,F) the scratch experiment (40×) was performed to evaluate the influence of SNHG12 on cell migration, and the (G,H) Transwell experiment (crystal violet; 100×) was used to assess the effect of SNHG12 on cell invasion. *, P<0.05. SNHG12, small nucleolar RNA host gene 12; CCK-8, Cell-Counting-Kit-8; EdU, 5-ethynyl-2'-deoxyuridine; NC, normal control.