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. 2022 Feb;10(4):224. doi: 10.21037/atm-21-6909

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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SENP1 affects the growth and cisplatin resistance of lung cancer cells in vivo. (A) SENP1-overexpression in A549 cells was detected by reverse transcription polymerase chain reaction (RT-PCR). (B) The survival rate of nude mice grafted with SENP1-overexpressed A549 cells. (C) The tumor volume of nude mice grafted with SENP1-overexpressed A549 cells. (D) The tumor volume of nude mice grafted with SENP1-overexpressed A549 cells with or without cisplatin treatment. (E) The body weight of nude mice grafted with SENP1-overexpressed A549 cells with or without cisplatin treatment. (F,G) Comparison of tumor weight (F) and representative volume (G) in each group. *, P<0.05 vs. control; **, P<0.01 vs. control; ***, P<0.001 vs. control.