Table 1. Demographic and Baseline Characteristics (Integrated Data)a.
| Characteristic | No. (%) | |||
|---|---|---|---|---|
| UPA 15 mg (n = 557) | UPA 30 mg (n = 567) | PBO/UPA 15 mg (n = 241) | PBO/UPA 30 mg (n = 244) | |
| Sex | ||||
| Female | 245 (44.0) | 250 (44.1) | 113 (46.9) | 119 (48.8) |
| Male | 312 (56.0) | 317 (55.9) | 128 (53.1) | 125 (51.2) |
| Age, mean (range), y | 33.7 (12-74) | 33.9 (12-75) | 33.3 (12-71) | 34.4 (12-75) |
| Age group, y | ||||
| <18 | 75 (13.5) | 77 (13.6) | 34 (14.1) | 35 (14.3) |
| ≥18 | 482 (86.5) | 490 (86.4) | 207 (85.9) | 209 (85.7) |
| Race and ethnicity | ||||
| American Indian/Alaska Native | 5 (0.9) | 2 (0.4) | 2 (0.8) | 5 (2.0) |
| Asian | 128 (23.0) | 133 (23.5) | 52 (21.6) | 53 (21.7) |
| Black or African American | 43 (7.7) | 25 (4.4) | 17 (7.1) | 16 (6.6) |
| Native Hawaiian or Other Pacific Islander | 3 (0.5) | 1 (0.2) | 1 (0.4) | 1 (0.4) |
| White | 366 (65.7) | 389 (68.6) | 164 (68.0) | 164 (67.2) |
| Multiple | 12 (2.2) | 17 (3.0) | 5 (2.1) | 5 (2.0) |
| Not Hispanic or Latino | 499 (89.6) | 504 (88.9) | 209 (86.7) | 218 (89.3) |
| Geographic region | ||||
| US/Puerto Rico/Canada | 234 (42.0) | 241 (42.5) | 103 (42.7) | 105 (43.0) |
| Japan | 15 (2.7) | 16 (2.8) | 5 (2.1) | 3 (1.2) |
| China | 14 (2.5) | 17 (3.0) | 5 (2.1) | 9 (3.7) |
| Other | 294 (52.8) | 293 (51.7) | 128 (53.1) | 127 (52.0) |
| BMI, mean (SD) | 25.8 (5.9) | 25.8 (5.8) | 26.8 (6.5) | 26.3 (5.5) |
| Disease duration since diagnosis, mean (SD), y | 19.7 (14.7) | 20.6 (14.3) | 21.3 (13.9) | 19.6 (14.2) |
| BSA affected, mean (SD), % | 46.8 (22.3) | 47.0 (22.6) | 47.0 (22.4) | 44.4 (22.2) |
| vIGA-AD | ||||
| Moderate (score of 3) | 280 (50.3) | 280 (49.4) | 119 (49.4) | 133 (54.5) |
| Severe (score of 4) | 277 (49.7) | 287 (50.6) | 122 (50.6) | 111 (45.5) |
| EASI, mean (SD) | 29.6 (12.3) | 29.3 (11.7) | 28.7 (12.6) | 28.4 (12.2) |
| Worst pruritus NRS, weekly average, mean (SD) | 7.2 (1.6) | 7.3 (1.5) | 7.2 (1.6) | 7.4 (1.6) |
| Worst pruritus NRS, daily average, mean (SD) | 7.3 (1.8) | 7.5 (1.7) | 7.4 (1.8) | 7.5 (1.8) |
| DLQI total score, mean (SD) | 16.6 (7.0) | 16.5 (6.9) | 16.7 (7.2) | 16.9 (6.9) |
| POEM total score, mean (SD) | 21.2 (4.9) | 21.6 (5.0) | 21.4 (5.5) | 21.9 (5.1) |
Abbreviations: BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; BSA, body surface area; DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; NRS, numeric rating scale; PBO, placebo; POEM, Patient-Oriented Eczema Measure; UPA, upadacitinib; vIGA-AD, Validated Investigator Global Assessment for Atopic Dermatitis.
a
Data from Measure Up 1 and Measure Up 2 studies.10 Values are based on nonmissing values from randomized patients.