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. 2022 Feb 24;13:790444. doi: 10.3389/fimmu.2022.790444

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Copyright © 2022 Durrant, Bucca, Hesketh, Möller-Levet, Tripkovic, Wu, Hart, Mathers, Elliott, Lanham-New and Smith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Selection of 98 subject participants from the Tripkovic et al. (2017) study (28) for transcriptomic analysis of their V1 (baseline) and V3 (12-week) samples in the present study; (B) Ethnicity and treatment group membership for the 97 subjects for which transcriptomic data was obtained (data for one South Asian subject from the placebo group did not pass quality control); (C) Metadata on serum concentrations of 25(OH)D₂, 25(OH)D₃, total 25(OH)D, PTH and calcium (albumin-adjusted) for the 97 subjects (see Supplementary Data File 1 for details). Participants were selected to provide comparable numbers between the placebo and the two vitamin D treatment groups, covering the full range of serum responses to supplementation within the D₂ and D₃ treatment groups, as judged from the measured changes in serum 25(OH)D₂ or 25(OH)D₃ concentrations between V1 and V3.