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. 2022 Feb 24;13:790444. doi: 10.3389/fimmu.2022.790444

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Copyright © 2022 Durrant, Bucca, Hesketh, Möller-Levet, Tripkovic, Wu, Hart, Mathers, Elliott, Lanham-New and Smith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein-protein interaction networks for gene products corresponding to the probes (A) significantly down-regulated or (B) significantly up-regulated in both the D₂ and D₃ treatment groups of the WE cohort, but not the placebo group. Details given in Supplementary Data File 3 . The networks were generated using the STRING database of Homo sapiens medium confidence (0.4) interactions, and only connected nodes are shown. Networks for both (A, B) are significantly enriched for interactions compared to randomised sets, yielding p-values of 1.98 × 10^-6 and 4.99 ×10^-9, respectively.