Figure 7.

A schematic diagram of this study in the context of genetic and seasonal factors that can influence physiological vitamin D status and the whole blood transcriptome. Dietary supplementation with vitamin D₂ or D₃ boosts the native levels of the active forms of these vitamins in the blood, and generates overlapping but different effects on the seasonal trends in gene expression. Non-supplemented placebo subjects remain on their natural trajectories for levels of active D₂ and D₃, and for their seasonal expression profile. Selected differentially expressed pathways from this study are indicated on the Venn diagram.