TABLE 3.

Genes related to blood-brain barrier.

BBB properties	Gene symbol	Log2 FC (EA/control)	Adjusted P-value
Tight junction integrity	Cgn	0.02	0.982
	Cgnl1	–0.09	0.954
	Cldn5	–11.59	0.306
	Ctnna1	–0.09	0.869
	Ctnna2	0.01	0.925
	Ctnnb1	–0.12	0.660
	Jaml	0.22	0.949
	Jam2	0.00	0.980
	Jam3	–0.04	0.978
	Ocln	–0.47	0.236
	Tjp1	–0.05	0.952
	Tjp2	–0.08	0.928
	Tjp3	0.25	0.889
	Marveld1	–0.21	0.830
	Marveld2	–0.49	0.715
	Marveld3	5.93	0.935
	Lsr	–0.34	0.268
	F11r	–0.12	0.899
	Emp1	–0.01	0.996
	Cgnl1	–0.09	0.954
	Pmp22	0.02	0.955
Slc transporters	Slc7a1	–0.80	0.033
	Slc9a3r2	–0.44	0.022
	Slc25a25	0.31	0.013
	Slc38a3	–0.29	0.002
	Slco2b1	–0.29	0.010
ABC transporters	Abca2	–0.23	0.022
	Abcb4	–0.24	0.116
	Abcc3	–0.57	0.148
	Abcc6	–0.66	0.015
	Abcd4	–0.14	0.924
	Abcg2	–0.25	0.658
LAMs	Sele	–1.26	0.836
	Selp	0.32	0.979
	Icam1	–0.20	0.877
	Vcam1	0.00	0.980
	Alcam	0.07	0.594
	Mcam	–0.07	0.962
	Ninj1	–0.05	0.980
Other transporters	Lrp1	–0.18	0.188
	Lrp10	–0.09	0.926
	Mfsd2a	–0.38	0.286
	Mfsd2b	–8.26	0.777
Transcytosis	Tfrc	0.10	0.602
	Cav1	–0.03	0.998
	Cav2	0.06	0.936
	Cav3	–8.05	0.835
	Cavin1	–0.42	0.659
	Cavin2	–0.62	0.035
	Cavin3	–0.25	0.381
	Cavin4	–0.41	0.863
Endocytosis	Arf1	–0.02	0.989
	Arf2	0.06	0.863
	Arf4	0.13	0.349
	Arf5	–0.07	0.935
	Cttn	–12.38	0.000
	Ccdc117	0.42	0.005
	Cdc42ep3	0.37	0.008
	Cdc45	–0.37	0.033
	Cblb	0.74	0.013
	Dnm1	–0.03	0.992
	Eps8	–0.17	0.374
	Eps15	–0.02	0.992
	Flot1	–0.12	0.879
	Flot2	0.29	0.101
	Fyn	0.12	0.352
	Hspa1b	2.67	0.000
	Hspa12b	–0.64	0.041
Angiogenesis	Angpt4	0.37	0.879
	Angpt1	0.03	0.980
	Angpt2	–0.10	0.970
	Egr1	0.03	0.961
	Egr2	0.13	0.861
	Egr3	0.03	0.935
	Egr4	–0.16	0.886
	Fgfr1	–0.13	0.507
	Fgfr2	–0.04	0.995
	Itgb1	0.03	0.922
	Itgb2	0.04	0.954
	Itgb3	–0.29	0.935
	Lgals1	–0.10	0.961
	Lgals2	–7.70	0.935
	Lgals3	–0.14	0.968
	Mmp9	–0.08	0.980
	Pdgfa	–0.07	0.953
	Pdgfb	–0.05	0.980
	Tgfb2	0.14	0.692
	Vegfa	–0.13	0.949
	Vegfb	–0.31	0.605

Genes in bold refer to differentially expressed genes (DEGs) identified by FC > 1.2 and q < 0.05.