TABLE 4.
Details of all gene ontology terms related to blood-brain barrier.
| GO function | GO ID | GO term | DEGs | P-value |
| BP | GO:0006811 | ion transport | Kcnt2, Ryr2, Kcng4, Kcnh4, Slco2b1, Kcnk4, Itpr3, Grin2c, Slc38a3 | 0.0056 |
| GO:0055085 | transmembrane transport | Abcc6, Itpr3, Ryr2, Slco2b1, Kcnh4, Kcng4, Slc25a25, Slc7a1 | 0.0248 | |
| GO:0001525 | angiogenesis | Plcd3, Scg2, Sox18, Efna1, Ccn3, Tie1 | 0.0014 | |
| GO:0007420 | brain development | Rgs2, Cttn, Cxcl12, Slc38a3, Sphk2 | 0.0251 | |
| GO:0006813 | potassium ion transport | Kcnt2, Kcnh4, Kcng4, Kcnk4 | 0.0087 | |
| GO:0071805 | potassium ion transmembrane transport | Kcnt2, Kcnk4, Kcnh4, Kcng4 | 0.0092 | |
| GO:0001568 | blood vessel development | Tie1, Sox18, Sphk2 | 0.0080 | |
| GO:0001938 | positive regulation of endothelial cell proliferation | Cxcl12, Scg2, Cyba | 0.0090 | |
| GO:0070588 | calcium ion transmembrane transport | Ryr2, Slc25a25, Itpr3 | 0.0353 | |
| GO:0035767 | endothelial cell chemotaxis | Coro1b, Ccn3 | 0.0008 | |
| GO:0060402 | calcium ion transport into cytosol | Ryr2, Itpr3 | 0.0011 | |
| GO:0090280 | positive regulation of calcium ion import | Cxcl12, Sphk2 | 0.0044 | |
| GO:0006865 | amino acid transport | Slc7a1, Slc38a3 | 0.0339 | |
| GO:1903810 | L-histidine import across plasma membrane | Slc7a1 | 0.0063 | |
| GO:2000487 | positive regulation of glutamine transport | Slc38a3 | 0.0063 | |
| GO:0015817 | histidine transport | Slc38a3 | 0.0063 | |
| GO:0051284 | positive regulation of sequestering of calcium ion | Ryr2 | 0.0125 | |
| GO:1901726 | negative regulation of histone deacetylase activity | Sphk2 | 0.0125 | |
| GO:0006867 | asparagine transport | Slc38a3 | 0.0125 | |
| GO:1900924 | negative regulation of glycine import across plasma membrane | Rgs2 | 0.0125 | |
| GO:0060401 | cytosolic calcium ion transport | Ryr2 | 0.0125 | |
| GO:0015819 | lysine transport | Slc7a1 | 0.0125 | |
| GO:0015822 | ornithine transport | Slc7a1 | 0.0187 | |
| GO:0071603 | endothelial cell-cell adhesion | Ccn3 | 0.0187 | |
| GO:1903826 | arginine transmembrane transport | Slc7a1 | 0.0187 | |
| GO:1901896 | positive regulation of ATPase-coupled calcium transmembrane transporter activity | Ryr2 | 0.0249 | |
| GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | Tmem204 | 0.0249 | |
| GO:0089709 | L-histidine transmembrane transport | Slc38a3 | 0.0249 | |
| GO:0015809 | arginine transport | Slc7a1 | 0.0311 | |
| GO:0043535 | regulation of blood vessel endothelial cell migration | Efna1 | 0.0311 | |
| GO:1990822 | basic amino acid transmembrane transport | Slc7a1 | 0.0311 | |
| GO:0071896 | protein localization to adherence junction | Scrib | 0.0311 | |
| GO:0097553 | calcium ion transmembrane import into cytosol | Grin2c | 0.0371 | |
| GO:0015807 | L-amino acid transport | Slc7a1 | 0.0371 | |
| GO:0006868 | glutamine transport | Slc38a3 | 0.0371 | |
| GO:0015808 | L-alanine transport | Slc38a3 | 0.0432 | |
| GO:1903348 | positive regulation of bicellular tight junction assembly | Nphp4 | 0.0432 | |
| GO:0043615 | astrocyte cell migration | Scrib | 0.0432 | |
| GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Ryr2 | 0.0492 | |
| GO:0038203 | TORC2 signaling | Prr5l | 0.0311 | |
| CC | GO:0016323 | basolateral plasma membrane | Slc38a3, Slc7a1, Abcc6, Hspa1b, Scrib | 0.0087 |
| GO:0062023 | collagen-containing extracellular matrix | Mgp, Vwf, Ltbp3, Ccn3 | 0.0072 | |
| GO:0005901 | caveola | Lipe, Cavin2, Htr2a | 0.0083 | |
| GO:0005905 | clathrin-coated pit | Cttn, Sh3bp4 | 0.0424 | |
| GO:0062023 | collagen-containing extracellular matrix | Mgp, Vwf, Ltbp3, Ccn3 | 0.0071 | |
| MF | GO:0005216 | ion channel activity | Itpr3, Kcnh4, Grin2c, Kcng4, Ryr2 | 0.0058 |
| GO:0005267 | potassium channel activity | Kcnk4, Kcnh4, Kcnt2, Kcng4 | 0.0014 | |
| GO:0005290 | L-histidine transmembrane transporter activity | Slc7a1, Slc38a3 | 0.0002 | |
| GO:0015278 | calcium-release channel activity | Itpr3, Ryr2 | 0.0014 | |
| GO:0015171 | amino acid transmembrane transporter activity | Slc38a3, Slc7a1 | 0.0133 | |
| GO:0098782 | mechanosensitived potassium channel activity | Kcnk4 | 0.0063 | |
| GO:0005228 | intracellular sodium activated potassium channel activity | Kcnt2 | 0.0063 | |
| GO:0070089 | chloride-activated potassium channel activity | Kcnt2 | 0.0063 | |
| GO:0015182 | L-asparagine transmembrane transporter activity | Slc38a3 | 0.0187 | |
| GO:0005219 | ryanodine-sensitive calcium-release channel activity | Ryr2 | 0.0187 | |
| GO:0048763 | calcium-induced calcium release activity | Ryr2 | 0.0249 | |
| GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity | Itpr3 | 0.0249 | |
| GO:0022849 | glutamate-gated calcium ion channel activity | Grin2c | 0.0311 | |
| GO:0015181 | arginine transmembrane transporter activity | Slc7a1 | 0.0311 | |
| GO:0015186 | L-glutamine transmembrane transporter activity | Slc38a3 | 0.0371 | |
| GO:0015174 | basic amino acid transmembrane transporter activity | Slc7a1 | 0.0371 | |
| GO:0004972 | NMDA glutamate receptor activity | Grin2c | 0.0371 | |
| GO:0015180 | L-alanine transmembrane transporter activity | Slc38a3 | 0.0492 | |
| GO:0015271 | outward rectifier potassium channel activity | Kcnt2 | 0.0492 | |
| GO:0005178 | integrin binding | Vwf, Ccn3, Cxcl12 | 0.0426 |