Table 2.
Univariate and multivariate analyses of clinicopathological factors of patients with pT1N2-3b GC
| Characteristic |
pT1N2-3b
|
|||
|
Univariate analysis
|
Multivariate analysis
|
|||
|
HR (95%CI)
|
P
value
|
HR (95%CI)
|
P
value
|
|
| Sex | 0.870 | - | - | |
| Male | 1.000 | |||
| Female | 0.929 (0.387-2.233) | |||
| Age (yr) | 1.044 (1.001-1.089) | 0.044 | 1.022 (0.978-1.069) | 0.335 |
| BMI (kg/m2) | 0.924 (0.815-1.047) | 0.216 | - | - |
| Neutrophils (109/L) | 1.034 (0.795-1.345) | 0.802 | - | - |
| Lymphocytes (109/L) | 0.616 (0.297-1.278) | 0.193 | - | - |
| Platelets (109/L) | 0.999 (0.992-1.006) | 0.692 | - | - |
| Fibrinogen (g/L) | 1.277 (0.723-2.256) | 0.399 | - | - |
| ALT (U/L) | 1.000 (0.973-1.029) | 0.972 | - | - |
| AST (U/L) | 1.016 (0.968-1.067) | 0.521 | - | - |
| Albumin (g/L) | 0.926 (0.833-1.028) | 0.150 | - | - |
| Prealbumin (mg/L) | 0.986 (0.977-0.995) | 0.003 | 0.990 (0.981-1.000) | 0.040 |
| CEA (ng/mL) | 1.254 (1.074-1.464) | 0.004 | 1.199 (1.028-1.399) | 0.021 |
| CA19-9 (U/mL) | 1.000 (0.972-1.028) | 0.992 | - | - |
| Tumor diameter (mm) | 0.986 (0.961-1.013) | 0.307 | - | - |
| Gastrectomy | 0.683 | - | - | |
| Partial gastrectomy | 1.000 | |||
| Total gastrectomy | 1.356 (0.314-5.851) | |||
| Histological type | 0.324 | - | - | |
| Differentiated | 1.000 | |||
| Undifferentiated | 1.665 (0.605-4.581) | |||
| pN stage | 0.251 | - | - | |
| N2 | 1.000 | |||
| N3 | 1.752 (0.673-4.562) | |||
| mLNR | 47.797 (5.421-421.417) | < 0.001 | 17.488 (1.215-251.748) | 0.035 |
| Vascular infiltration | 0.187 | - | - | |
| No | 1.000 | |||
| Yes | 1.865 (0.738-4.708) | |||
| Nerve infiltration | 0.989 | - | - | |
| No | 1.000 | |||
| Yes | 1.010 (0.234-4.359) | |||
| Postoperative chemotherapy | 0.528 | - | - | |
| Yes | 1.000 | |||
| No | 0.744 (0.297-1.865) | |||
CEA and CA19-9 were according to the tumor marker examination. Tumor location, histological type, mLNR, pTstage, pNstage, vascular infiltration, and nerve infiltration were according to the postoperative pathology report. Statistically significant P values are in bold (P < 0.05). HR: Hazard ratio; CI: Confidence interval; BMI: Body mass index; ALT: Alanine transaminase; AST: A CEA: Carcino-embryonic antigen; CA19-9: Carbohydrate antigen 19-9; mLNR: Metastatic lymph node ratio.