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. 2022 Feb 24;13:835620. doi: 10.3389/fmicb.2022.835620

FIGURE 3.

FIGURE 3

Variables when designing high-throughput transcriptomic studies. Diverse parameters must be taken into account when designing new TB studies involving HTTr. Some of them include: (1) the infection model: in vitro (cell infection) or in vivo (animals or TB patients) (2) type of bacteria (i.e., strain, mutated or wild-type) and culture conditions; (3) samples to be collected (saliva, sputum, blood, etc.), including analysis of immune cells or subpopulations, at basal level or after stimulation; (4) the stage of the disease (i.e., active disease, latency, early clearance); (5) target element: bacteria, host or both, and (6) the HTTr platform most adequate for the study.