TABLE 1.

Advantages and disadvantages of microarrays and RNA-sequencing for gene expression analysis.

	Microarray	RNA-seq
Advantages	• Standardized analysis: Easier to analyze. • Moderately lower cost.	• Broader dynamic range (< 105) and sensitivity (Zhao et al., 2014). • Allows modification of sequencing coverage depth to detect rare and low-abundance transcripts. • Allows the detection of novel transcripts, splicing variants, single nucleotide variants, insertions, deletions and gene fusions.
Disadvantages	• Lower dynamic range (103–104). • Does not allow the detection of novel transcripts (uses pre-designed probes).	• Large size of files: Demands considerable amount of computer resources for storage and analysis. • Lack of standardized protocol for analysis: Complex computational analysis and longer analysis times.