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. 2022 Feb 17;23(4):291. doi: 10.3892/etm.2022.11220

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Copyright: © Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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S100A9 blockade relieves inflammation and apoptosis after SCI. (A) Immunohistochemistry for MPO at the lesion site 28 days post-OR among groups. (B) mRNA expression level of pro-inflammatory genes (IL-1β, IL-6 and TNF-α) and anti-inflammatory genes (IL-4 and IL-10) at the injury site 28 days post-OR among the groups. (C) Protein expression level of Bcl2, Bax and cleaved caspase-3 at the injury site 28 days post-OR among the groups. n=5. ^***P<0.001. ^#P<0.05, ^###P<0.001. Scale bar, 200 µm. S100A9, S100 calcium-binding protein A9; SCI, spinal cord injury; MPO, myeloperoxidase; post-OR, after the operation; High-ABR, high ABR dose; Low-ABR, low ABR dose; n.s, not significant.