Figure 5.

Production of HP [1-¹³C]lactate (A) and HP [1-¹³C]β-HB (B) in the hearts following the injection of co-polarized [1-¹³C]pyruvate and [1,3-¹³C₂]AcAc. Intensities of HP [1-¹³C]lactate were normalized to HP [1-¹³C]alanine produced by the same heart. HP [1-¹³C]β-HB intensities were normalized to HP [1-¹³C]acetyl-carnitine. Data are presented as the mean ± SEM (n = 4 per group) with statistical significance of differences indicated by “*” (P < 0.05) and “**” (P < 0.001).