Figure 7.

(a) Detection of the intracellular levels of NO generated by DXNO-GR or DOX in the absence or in the presence of green light irradiation. NO increment is expressed as increase of DAF-FM probe fluorescence with respect to the fluorescence signal measured in control cells and set equal to 1 (fold change). *p < 0.001 significantly different from dark sample (Student’s t-test). #p < 0.01; ##p < 0.001 significant difference between DOX and DXNO-GR (Student’s t-test). (b) Inhibition of MDR efflux pumps measured through the retention of the substrate EFLUXX-ID. *p < 0.001 significantly different from dark sample (Student’s t-test).