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. 2022 Feb 23;7(9):8174–8183. doi: 10.1021/acsomega.2c00297

Figure 1.

Figure 1

Characterization of microRNA nanocarriers. (A) Schematic illustration of the synthesis of microRNA nanocarriers. (I) Enriching of the monomers and cross-linkers around microRNA molecules. (II) Formation of Ng(miR-155) by free radical polymerization. (III) Release of microRNA-155 from the nanocarrier upon degradation of the polymer shell. MicroRNA-155 was taken as an example. (B) Particle size distribution of nanocarriers by DLS. (C) TEM images of nanocarriers. (D) ζ potential of miRNA-155 and Ng(miR-155). (E) Agarose gel electrophoresis. Native miR-155 served as the control.