Table 1.
Population-based studies evaluating the relationship between blood pressure and ocular perfusion pressures and glaucoma prevalence, incidence and progression. DBP: diastolic blood pressure; DOPP: diastolic ocular perfusion pressure; IOP: intraocular pressure; MOPP: mean ocular perfusion pressure; N: number of study subjects; NTG: normal tension glaucoma; OAG: open-angle glaucoma; OPPs: ocular perfusion pressures; POAG: primary open-angle glaucoma; SOPP: systolic ocular perfusion pressure.
| Study | N | Findings | |
|---|---|---|---|
| Prevalence | Baltimore Eye Survey (1995) | 5308 (African and European descent) | Low DOPP and OAG risk |
| Barbados Eye Study (1995) | 4314 (African descent) | Low DOPP and OAG risk | |
| Egna-Neumarkt Study (2000) | 4297 (European descent) | Low DOPP and high-pressure OAG | |
| Proyecto (2001) | 4774 (Latin descent) | Low DOPP and OAG risk | |
| Rotterdam Study (2007) | 5317 (European descent) | Low DOPP and hypertensive OAG risk (patients treated for systemic hypertension) | |
| Beijing Eye Study (2009) | 3251 (Asian descent, Chinese) | No statistically significant association between OPPs (MOPP, DOPP, SOPP) and OAG risk | |
| Los Angeles Latino Eye Study (2010) | 6130 (Latin descent) | Low MOPP, DOPP, SOPP and OAG risk | |
| Singapore Malay Eye Study (2010) | 3280 (Asian descent, Malay) | Low MOPP and DOPP and OAG risk | |
| Thessaloniki Eye Study (2013) | 2554 (European descent) | Low DOPP and OAG risk (patients treated for systemic hypertension) | |
| South India Study (2014) | 208 (Asian descent, Indian) | Low MOPP and OAG risk (patients treated for systemic hypertension) | |
| The Handan Eye Study (2016) | 6830 (Asian descent, Han Chinese) | Low MOPP, DOPP and SOPP and OAG risk | |
| Nigeria National Blindness and Visual Impairment Survey (2016) | 13,591 (African descent) | Low MOPP and OAG risk | |
| Cantor et al. (2018) | 1272 (Latin descent) | Low MOPP and DOPP, high SOPP, high DBP and OAG risk (patients treated for systemic hypertension) | |
| Singapore Epidemiology of Eye Diseases Study (2018) | 9877 participants (Asian descent, multiethnic) | Low and high SOPP and OAG risk | |
| Incidence | Barbados Eye Study (mean follow up: 9 years) (2008) | 3222 (African descent) | Low MOPP, DOPP, and SOPP and incident OAG |
| Rotterdam Study (mean follow up: 9.8 years) (2011) | 3882 (European descent) | Low MOPP and incident OAG (no statistical significance after IOP adjustment) | |
| Rotterdam Study (mean follow up: 12.1 years) (2017) | 3939 (European descent) | DBP not associated with incident OAG (no analysis for OPPs) | |
| Progression | Early Manifest Glaucoma Trial (mean follow up: 8 years) (2007) | 255 (early OAG) | Lower baseline SOPP and OAG perimetric and structural progression |
| Low-pressure Glaucoma Treatment Study (mean follow up: 40.6 months) (2012) | 127 (NTG) | Lower MOPP during follow-up and perimetric progression | |
| Jin at al. (mean follow up: 21.2 years) (2017) | 72 (NTG) | Lower MOPP and perimetric progression |