Table 2.

Diagnostic performance for discriminating mild cognitive impairment (MCI) and Alzheimer’s disease (AD), MCI, and AD from cognitively normal controls

No.	Parameter	Area under the receiver operating characteristic curve (95% confidence interval)	Sensitivity at 80% specificity	p value
A) MCI and AD vs control
1	Measured cpRNFL thickness	0.69 (0.62–0.75)	42.7	Ref
2	Retinal vessel density	0.61 (0.55–0.68)	35.9	0.080
3	Macular layers (mRNFL, mGCL and mIPL)	0.73 (0.68–0.79)	51.5	0.189
4	Compensated cpRNFL thickness and multiple ocular factors	0.74 (0.68–0.80)	56.3	0.026
5	Combined (#3 and #4)	0.80 (0.75–0.86)	68.0	< 0.001
B) MCI vs control
1	Measured cpRNFL thickness	0.68 (0.61–0.74)	42.7	Ref
2	Retinal vessel density	0.60 (0.53–0.67)	34.0	0.092
3	Macular layers (mRNFL, mGCL and mIPL)	0.71 (0.65–0.78)	45.6	0.393
4	Compensated cpRNFL thickness and multiple ocular factors	0.74 (0.67–0.80)	59.2	0.020
5	Combined (#3 and #4)	0.79 (0.73–0.85)	67.0	< 0.001
C) AD vs control
1	Measured cpRNFL thickness	0.71 (0.63–0.78)	36.9	Ref
2	Retinal vessel density	0.64 (0.56–0.72)	30.1	0.225
3	Macular layers (mRNFL, mGCL and mIPL)	0.76 (0.70–0.83)	56.3	0.086
4	Compensated cpRNFL thickness and multiple ocular factors	0.79 (0.72–0.85)	56.3	0.025
5	Combined (#3 and #4)	0.87 (0.82–0.92)	74.8	< 0.001
D) MCI vs AD
1	Measured cpRNFL thickness	0.58 (0.51–0.66)	26.9	Ref
2	Retinal vessel density	0.59 (0.51–0.67)	36.3	0.916
3	Macular layers (mRNFL, mGCL and mIPL)	0.66 (0.58–0.74)	37.2	0.129
4	Compensated cpRNFL thickness and multiple ocular factors	0.64 (0.56–0.71)	35.9	0.112
5	Combined (#3 and #4)	0.72 (0.65–0.79)	42.1	0.003

Results for sensitivity is expressed as percentages. P value indicates the paired comparisons with the best parameter (reference group)

cpRNFL circumpapillary retinal nerve fiber layer, mRNFL macular retinal nerve fiber layer, mGCL macular ganglion cell layer, mIPL macular inner plexiform layer