Table 2.
Main characteristics of the antidiabetic drugs included in the PPI network
| Name | Drugbank ID | Target genes | Target type |
|---|---|---|---|
| Ebselen | DB12610 | EPHX2 | Target |
| INCB13739 | DB05064 | HSD11B1 | Target |
| PSN357 | DB05044 | PYGL | Target |
| Bisegliptin | DB06127 | DPP4 | Target |
| NOX-700 | DB05464 | NFKB2 | Target |
| NFKB1 | Target | ||
| CLX-0921 | DB05854 | PPARG | Target |
| Reglitazar | DB04971 | PPARA | Target |
| PPARG | Target | ||
| ISIS 113715 | DB05506 | PTPN1 | Target |
| AT1391 | DB05120 | INSR | Target |
| NN344 | DB05115 | INSR | Target |
| CYP1A2 | Enzyme | ||
| APD668 | DB05166 | GPR119 | Target |
| Dutogliptin | DB11723 | DPP4 | Target |
| MB-07803 | DB05053 | FBP1 | Target |
| PSN9301 | DB05001 | DPP4 | Target |
| Gliquidone | DB01251 | ABCC8 | Target |
| KCNJ8 | Target | ||
| CYP2C9 | Enzyme | ||
| Albiglutide | DB09043 | GLP1R | Target |
| Pramlintide | DB01278 | CALCR | Target |
| RAMP1 | Target | ||
| RAMP2 | Target | ||
| RAMP3 | Target | ||
| Voglibose | DB04878 | MGAM | Target |
| Dapagliflozin | DB06292 | SLC5A2 | Target |
| CYP1A1 | Enzyme | ||
| CYP1A2 | Enzyme | ||
| CYP2A6 | Enzyme | ||
| CYP2C9 | Enzyme | ||
| CYP2D6 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| UGT1A9 | Enzyme | ||
| UGT2B4 | Enzyme | ||
| UGT2B7 | Enzyme | ||
| Miglitol | DB00491 | MGAM | Target |
| GAA | Target | ||
| GANAB | Target | ||
| GANC | Target | ||
| AMY2A | Enzyme | ||
| Vildagliptin | DB04876 | DPP4 | Target |
| Dulaglutide | DB09045 | GLP1R | Target |
| Phenformin | DB00914 | PRKAA1 | Target |
| KCNJ8 | Target | ||
| CYP2D6 | Enzyme | ||
| AMG-131 | DB05490 | PPARG | Target |
| Acarbose | DB00284 | MGAM | Target |
| GAA | Target | ||
| SI | Target | ||
| AMY2A | Target | ||
| Sitagliptin | DB01261 | DPP4 | Target |
| CYP3A4 | Enzyme | ||
| CYP2C8 | Enzyme | ||
| Acetohexamide | DB00414 | KCNJ1 | Target |
| CBR1 | Enzyme | ||
| CYP2C9 | Enzyme | ||
| Canagliflozin | DB08907 | SLC5A2 | Target |
| UGT1A9 | Enzyme | ||
| UGT2B4 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| Pioglitazone | DB01132 | PPARG | Target |
| MAOB | Target | ||
| CYP2C8 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| CYP1A1 | Enzyme | ||
| Glisoxepide | DB01289 | KCNJ8 | Target |
| CYP2C9 | Enzyme | ||
| Glipizide | DB01067 | ABCC8 | Target |
| PPARG | Target | ||
| CYP2C9 | Enzyme | ||
| UGT1A1 | Enzyme | ||
| Insulin Glargine | DB00047 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| Insulin Degludec | DB09564 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| Chlorpropamide | DB00672 | ABCC8 | Target |
| CYP2C9 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| PTGS1 | Enzyme | ||
| Linagliptin | DB08882 | DPP4 | Target |
| CYP3A4 | Enzyme | ||
| Repaglinide | DB00912 | ABCC8 | Target |
| PPARG | Target | ||
| CYP2C8 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| Insulin Pork | DB00071 | INSR | Target |
| IGF1R | Target | ||
| IDE | Enzyme | ||
| CYP1A2 | Enzyme | ||
| Nateglinide | DB00731 | ABCC8 | Target |
| PPARG | Target | ||
| CYP2C9 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| CYP3A5 | Enzyme | ||
| CYP3A7 | Enzyme | ||
| PTGS1 | Enzyme | ||
| UGT1A9 | Enzyme | ||
| CYP2D6 | Enzyme | ||
| Insulin Aspart | DB01306 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| Insulin Detemir | DB01307 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| Saxagliptin | DB06335 | DPP4 | Target |
| CYP3A4 | Enzyme | ||
| CYP3A5 | Enzyme | ||
| Insulin Glulisine | DB01309 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| Tolbutamide | DB01124 | ABCC8 | Target |
| KCNJ1 | Target | ||
| CYP2C9 | Enzyme | ||
| CYP2C8 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| CYP2C18 | Enzyme | ||
| Rosiglitazone | DB00412 | PPARG | Target |
| ACSL4 | Target | ||
| PPARA | Target | ||
| PPARD | Target | ||
| RXRA | Target | ||
| RXRB | Target | ||
| RXRG | Target | ||
| CYP2C8 | Enzyme | ||
| CYP2C9 | Enzyme | ||
| PTGS1 | Enzyme | ||
| CYP1A2 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| CYP2B6 | Enzyme | ||
| CYP2D6 | Enzyme | ||
| CYP2E1 | Enzyme | ||
| Mitiglinide | DB01252 | ABCC8 | Target |
| PPARG | Target | ||
| UGT1A3 | Enzyme | ||
| UGT2B7 | Enzyme | ||
| Insulin Human | DB00030 | INSR | Target |
| IGF1R | Target | ||
| CPE | Target | ||
| NOV | Target | ||
| LRP2 | Target | ||
| IGFBP7 | Target | ||
| IDE | Enzyme | ||
| PCSK2 | Enzyme | ||
| PCSK1 | Enzyme | ||
| CYP1A2 | Enzyme | ||
| Insulin Lispro | DB00046 | INSR | Target |
| IGF1R | Target | ||
| CYP1A2 | Enzyme | ||
| IDE | Enzyme | ||
| Lixisenatide | DB09265 | GLP1R | Target |
| Metformin | DB00331 | PRKAB1 | Target |
| ETFDH | Target | ||
| GPD1 | Target | ||
| Lobeglitazone | DB09198 | PPARG | Target |
| CYP1A2 | Enzyme | ||
| CYP2C9 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| Managlinat dialanetil | DB05518 | FBP1 | Target |
| Levoketoconazole | DB05667 | CYP11B1 | Target |
| CYP51A1 | Target | ||
| CYP3A4 | Enzyme | ||
| CYP3A5 | Enzyme | ||
| CYP51A1 | Enzyme | ||
| CYP17A1 | Enzyme | ||
| CYP21A2 | Enzyme | ||
| CYP11B1 | Enzyme | ||
| Tesaglitazar | DB06536 | PPARA | Target |
| PPARG | Target | ||
| Ertiprotafib | DB06521 | PTPN1 | Target |
| IKBKB | Target | ||
| PPARA | Target | ||
| PPARG | Target | ||
| Glycodiazine | DB01382 | KCNJ1 | Target |
| ABCC8 | Target | ||
| Muraglitazar | DB06510 | PPARA | Target |
| PPARG | Target | ||
| CYP1A2 | Enzyme | ||
| UGT1A3 | Enzyme | ||
| UGT1A1 | Enzyme | ||
| CYP2C8 | Enzyme | ||
| Troglitazone | DB00197 | PPARG | Target |
| ACSL4 | Target | ||
| SERPINE1 | Target | ||
| SLC29A1 | Target | ||
| ESRRG | Target | ||
| ESRRA | Target | ||
| PPARD | Target | ||
| PPARA | Target | ||
| GSTP1 | Target | ||
| CYP3A4 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| UGT1A1 | Enzyme | ||
| CYP2C8 | Enzyme | ||
| CYP19A1 | Enzyme | ||
| CYP1A1 | Enzyme | ||
| CYP2B6 | Enzyme | ||
| CYP2C9 | Enzyme | ||
| CYP3A5 | Enzyme | ||
| CYP3A7 | Enzyme | ||
| UGT1A3 | Enzyme | ||
| UGT1A4 | Enzyme | ||
| UGT1A6 | Enzyme | ||
| UGT1A7 | Enzyme | ||
| UGT1A8 | Enzyme | ||
| UGT1A9 | Enzyme | ||
| UGT1A10 | Enzyme | ||
| UGT2B7 | Enzyme | ||
| UGT2B15 | Enzyme | ||
| Ertugliflozin | DB11827 | SLC5A2 | Target |
| UGT1A9 | Enzyme | ||
| UGT2B7 | Enzyme | ||
| UGT1A1 | Enzyme | ||
| UGT1A4 | Enzyme | ||
| Exenatide | DB01276 | GLP1R | Target |
| DPP4 | Enzyme | ||
| Naveglitazar | DB12662 | PPARG | Target |
| Alogliptin | DB06203 | DPP4 | Target |
| CYP3A4 | Enzyme | ||
| CYP2D6 | Enzyme | ||
| Liraglutide | DB06655 | GLP1R | Target |
| DPP4 | Enzyme | ||
| MME | Enzyme | ||
| Semaglutide | DB13928 | GLP1R | Target |
| DPP4 | Enzyme | ||
| MME | Enzyme | ||
| LPL | Enzyme | ||
| AMY1A | Enzyme | ||
| Glimepiride | DB00222 | KCNJ11 | Target |
| KCNJ1 | Target | ||
| ABCC8 | Target | ||
| CYP2C9 | Enzyme | ||
| Sarpogrelate | DB12163 | HTR2C | Target |
| HTR2A | Target | ||
| Glyburide | DB01016 | ABCC9 | Target |
| ABCB11 | Target | ||
| ABCA1 | Target | ||
| CFTR | Target | ||
| CPT1A | Target | ||
| TRPM4 | Target | ||
| CYP2C9 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| CYP3A4 | Enzyme | ||
| CYP3A7 | Enzyme | ||
| CYP3A5 | Enzyme | ||
| Gliclazide | DB01120 | ABCC8 | Target |
| VEGFA | Target | ||
| CYP2C9 | Enzyme | ||
| CYP2C19 | Enzyme | ||
| Empagliflozin | DB09038 | SLC5A2 | Target |
| UGT2B7 | Enzyme | ||
| UGT1A3 | Enzyme | ||
| UGT1A8 | Enzyme | ||
| UGT1A9 | Enzyme | ||
| Glymidine | DB01382 | KCNJ1 | Target |
| ABCC8 | Target | ||
| Balaglitazone | DB12781 | CYP3A4 | Enzyme |
| CYP2C8 | Enzyme | ||
| Glibornuride | DB08962 | CYP2C9 | Enzyme |
| Rivoglitazone | DB09200 | CYP3A4 | Enzyme |
| CYP2C8 | Enzyme | ||
| AB192 | DB06111 | MPO | Enzyme |
| Lisofylline | DB12406 | CYP1A2 | Enzyme |