Table 3.

2SMR estimates of the causality between antidiabetic targets and AD

Target gene	Drugs	Action	Method	Numbers of SNPs	OR	95% CI	P-value
CPE	Insulin Human	Modulator (Unknown)	MR Egger	3	0.98	0.82–1.17	0.86
			Inverse variance weighted	3	0.94	0.89–1.00	0.05
			Weighted median	3	0.95	0.89–1.01	0.08
			Weighted mode	3	0.95	0.89–1.01	0.24
ETFDH	Metformin	Inhibitor	Inverse variance weighted	2	1.08	1.01–1.16	0.03
GANC	Miglitol	Antagonist	Inverse variance weighted	2	1.09	1.02–1.18	0.02
MGAM	Voglibose	Inhibitor	Wald ratio	1	1.04	1.00–1.09	0.04
	Acarbose	Inhibitor
	Miglitol	Antagonist, inhibitor