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. 2022 Mar 9;22:14. doi: 10.1186/s40644-022-00452-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A 53-year-old patient with low-risk endometrial carcinoma. (a) On oblique axial DCE-MRI, tumor is delineated by red line and AIF is delineated by red circle. (b) Immunohistochemical staining with CD105 (magnification 400) showed 14 microvessels per mm² indicating low microvessel density in the tumour. (c) Parametric map of transfer constant (Ktrans) for the extended Tofts (ET) model. The mean value of Ktrans for the tumor was 0.12 min^-1, indicating relatively high permeability. (d) Parametric map of blood flow (F) for the distributed parameter (DP) model. The mean value of F for the tumor was 13.74 mL/min/100 mL, indicating relatively high blood flow. (e) Example of fitting a voxel tissue concentration (Ctiss)–time curve with the extended Tofts (ET) model and the distributed parameter (DP) model (right panel). Smaller sum-of-squared residue (SSR) is indicative of better fit. The ET and the DP model yield similar SSR values