Table 2.
Parameter values and P values derived with the ET and DP models
| Low-risk type Median (95% CI) |
High-risk type Median (95% CI) |
P value | Corrected P value | |
|---|---|---|---|---|
| ET model | ||||
| Ktrans | 0.10 (0.09–0.12) | 0.05 (0.04–0.05) | < 0.001 | < 0.001* |
| Vp | 1.02 (0.82–1.14) | 0.58 (0.38–0.74) | < 0.001 | < 0.001* |
| Ve | 8.12 (6.50–10.23) | 7.86 (6.95–8.96) | 0.39 | 0.39 |
| Kep | 1.20 (0.94–1.44) | 0.57 (0.51–0.68) | < 0.001 | < 0.001* |
| DP model | ||||
| F | 13.01 (12.26–14.79) | 8.12 (6.86–8.74) | < 0.001 | < 0.001* |
| MTT | 15.15 (12.12–17.33) | 12.38 (11.03–14.19) | 0.08 | 0.13 |
| Vp | 3.03 (2.37–3.69) | 1.46 (1.22–2.02) | < 0.001 | < 0.001* |
| Ve | 6.17 (4.88–8.06) | 6.31 (5.74–8.09) | 0.61 | 0.61 |
| PS | 8.32 (6.75–10.74) | 4.01 (3.16–5.14) | < 0.001 | < 0.001* |
| E | 43.63 (37.02–51.29) | 38.72 (34.42–47.26) | 0.52 | 0.63 |
* Significant P values
ET extended Tofts, DP distributed parameter, Ktrans transfer constant, Kep efflux rate constant, Vp blood volume, Ve extravascular extracellular volume, F blood flow, MTT mean transit time, PS permeability surface area product, E extraction fraction. Ktrans and Kep are in units of min−1, Vp and Ve are in units of mL/100 mL, F and PS are in units of mL/min/100 mL, MTT is in unit of seconds, E is in unit of %