2.

Recurrence and treatment for recurrence flow diagram 
 * Otto et al (unpublished) supplied overall survival data only. Patients who recurred on the control arm received 2 cycles of MVEC (PJ Goebell, pers comm.). 
 † Treatment on recurrence data not available for 3 trials [4‐6]. However, for one trial [6] patients randomised to control were treated with standard CMV on first evidence of recurrence and for another trial [5] there was no restriction on patients randomised to control arm receiving chemotherapy on recurrence / progression. For the final trial [4] patients randomised to the control arm were not recommended to receive chemotherapy on recurrence.