Table 3.
CyTOF profiling of P1 and his family members
| Percentage of total | Father | Mother | Brother | Patient | ||
|---|---|---|---|---|---|---|
| pDCs (calculated) | 0.46 | 1.05 | 0.37 | 0.77 | ||
| mDCs | CD1c+ | 0.46 | 0.75 | 0.52 | 0.33 | |
| CD141+ | 0.03 | 0.02 | 0.01 | 0.06 | ||
| Total | 2.63 | 1.30 | 0.96 | 0.98 | ||
| Monocytes | Mo1 | 9.71 | 14.42 | 12.15 | 6.82 | |
| Mo2 | 0.26 | 0.26 | 0.37 | 0.21 | ||
| Mo3 | 0.25 | 0.29 | 0.38 | 0.30 | ||
| NK cells | NK1 | 2.81 | 1.83 | 3.26 | 1.00 | |
| NK2 | 0.24 | 0.08 | 0.24 | 0.32 | ||
| NK3 | 24.32 | 28.33 | 20.60 | 13.87 | ||
| T cells | ||||||
| CD8+ | Naive | 3.97 | 12.04 | 12.27 | 20.82 | |
| EMRA | 2.73 | 2.36 | 9.06 | 9.38 | ||
| CM | 1.41 | 2.78 | 1.30 | 2.12 | ||
| EM | 10.08 | 4.66 | 6.65 | 7.38 | ||
| CD4+ | Naive | 16.73 | 16.88 | 15.86 | 20.93 | |
| EMRA | 2.61 | 1.80 | 2.26 | 2.05 | ||
| CM | 9.40 | 6.11 | 2.49 | 4.27 | ||
| EM | 4.85 | 2.31 | 2.15 | 2.06 | ||
| NKT cells | 0.00 | 0.14 | 0.11 | 0.05 | ||
| CD4+ | Th1 | 2.57 | 1.03 | 0.93 | 1.20 | |
| Th2 | 29.70 | 24.50 | 20.83 | 27.28 | ||
| Th17 | 0.86 | 1.22 | 0.83 | 0.51 | ||
| MAIT | 0.245 | 0.852 | 0.316 | 0.036 | ||
| ILCs | ILC1 | 0.032 | 0.077 | 0.076 | 0.045 | |
| ILC2 | 0.017 | 0.080 | 0.085 | 0.03 | ||
| ILC3 | 0.016 | 0.034 | 0.058 | 0.018 | ||
| Total | 0.026 | 0.111 | 0.132 | 0.027 | ||
CM, central memory; EM, effector memory; EMRA, effector memory cells re-expressing CD45RA; mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cell.