TABLE 1.
Current medications in use for TB treatment and their notable side-effects
| Drug | Notable side-effects |
| Rifampicin (RIF) | Hepatotoxicity, nausea, dyspepsia, abdominal pain, rash, CYP450 interactions |
| Isoniazid (INH) | Hepatotoxicity, peripheral neuropathy#, optic neuritis, CYP450 interactions |
| Pyrazinamide (PZA) | GI disturbance, hepatotoxicity, gout |
| Ethambutol (EMB) | Optic neuropathy |
| Levofloxacin (LFX)/Moxifloxacin (MFX) | QT prolongation, tendonitis, hypoglycaemia, psychiatric disturbance |
| Bedaquiline (BDQ) | QT prolongation, CYP450 interactions |
| Linezolid (LZD) | Myelosuppression, dysglycaemia, peripheral neuropathy#, optic neuropathy |
| Clofazimine (CFZ) | Hepatotoxicity, GI disturbance, neurological disturbance, QT prolongation, altered skin pigmentation |
| Cycloserine (CYS) | Psychiatric disturbance, peripheral neuropathy |
| Delamanid (DLM) | QT prolongation, CYP450 interactions |
| Aminoglycosides (AMK,CAP, STR) | Nephrotoxicity, ototoxicity |
| Ethionamide (ETH)/Prothionamide (Pro) | Psychiatric disturbance, peripheral neuropathy, hepatotoxicity, hypothyroidism, dysglycaemia |
| p-Aminosalicylic acid (PAS) | Hepatotoxicity, dysglycaemia, hypothyroidism |
| Amoxicillin–Clavulanate¶ with Meropenem or Imipenem–Cilastatin | Diarrhoea, candidiasis |
#: given with pyridoxine prophylaxis to ameliorate risk; ¶: beta-lactams must be given with Clavulanate for success in TB treatment; however, the only available preparations include Amoxicillin. Information from [50].