TABLE 2.

Current ATS/CDC/ERS/IDSA consolidated guidelines on treating drug-resistant TB

RR-TB
As per MDR-TB
INH-resistant TB
RIF+PZA+ETM+FLQ for 6 months (can discontinue PZA after 2 months; FLQ only required in patients with extensive disease, i.e. cavitary or bilateral infiltrates)
MDR-TB
First line	Levofloxacin or Moxifloxacin with all 4 of: Bedaquiline + Linezolid + Clofazimine# + Cycloserine#
Second line	Consider Delamanid¶2 or Pyrazinamide¶3 or Ethambutol¶1 or Amikacin or Streptomycin¶5
Third line	Consider ETH¶6 or Prothionamide or Imipenem-Cilastatin/Clavulante or Meropenem/Clavulanate¶4 or p-Aminosalicylic Acid¶7 or High Dose Isoniazid

ATS: American Thoracic Society; CDC: US Centers For Disease Control And Prevention; ERS: European Respiratory Society; IDSA: Infectious Diseases Society of America. ^#: in contrast, the WHO suggests only one of these drugs are required, comprising a 4-drug regimen (see text for full details); ^¶: superscript numbers refer to the order in which the WHO suggests drugs be incorporated into regimes. Information from [50].