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. 2022 Feb 24;10:816209. doi: 10.3389/fbioe.2022.816209

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Copyright © 2022 Zheng, Li, Zhang, Xu and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SMSC-212-5p-Exos attenuated IL-1β induced inflammatory responses in chondrocytes. IL-1β induced chondrocytes were treated with SMSC-Exos or SMSC-212-5p-Exos for 48 h. IL-6, MCP-1, and TNF-α production in cellular supernatant were measured by ELISA (A–C). mRNA levels of IL-6, COX-2, and iNOS from cell lysis were tested by qRT-PCR (D–F). n = 6 for each group in ELISA analysis, n = 3 for each group in qRT-PCR test. ##p < 0.01, ###p < 0.001 compared to NC. @p < 0.05, @@p < 0.01, @@@p < 0.001 compared to IL-1β. &p < 0.05, &&p < 0.01 compared to IL-1β+Exo. One-way ANOVA followed Dunn’s multiple comparisons test.