Figure 2.

MiR-185-5p mimic decreased atherosclerotic lesions in HFD-fed apoE^−/− mice. To induce atherosclerosis, apoE^−/− mice fed a high-fat diet were administered with miR-185-5p mimic via tail vein once every 2 weeks for 12 weeks. (A) hepatic cholesterol levels and serum cholesterol levels, (B) The descending arteries were obtained from the apoE^−/− mice and stained with Oil-red-O to examine the plaque formation. (C) The longitudinal section of the mice's aortic root was stained with Oil red O to examine the lesion area.