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. 2022 Feb 27;14(4):1691–1712. doi: 10.18632/aging.203918

Table 2. Association between GrimAA and cognitive function.

Analysis type Stroop test RAVLT long delay recall DSST
Coefficient (95% CI) p Adj.p1 n Coefficient (95% CI) p Adj.p1 n Coefficient (95% CI) p Adj.p1 n
5-year prospective analysis2
(Y20 epigenetic aging vs.
Y25 Cognition)		 0.194 (0.050,0.338) 0.009 0.013 925 -0.046 (-0.087,-0.005) 0.028 0.028 932 -0.308 (-0.505,-0.110) 0.002 0.007 931
15-year prospective analysis2
(Y15 epigenetic aging vs.
Y30 Cognition)		 0.231 (0.069,0.394) 0.005 0.008 890 -0.048 (-0.091,-0.005) 0.029 0.029 905 -0.404 (-0.614,-0.195) <0.001 <0.001 906
Delta analysis
(5-year change in GrimAA vs. 5-year change in cognition)		 0.006 (-0.159, 0.170) 0.946 0.946 741 0.049 (0.000,0.098) 0.049 0.147 754 0.076 (-0.093, 0.245) 0.380 0.569 754

1BH-FDR adjustment was applied to account for multiple testing for each aging marker across all the cognitive function tests.

2Multiple linear regression models adjusting for age, sex, race, study fields, and education. Beta coefficients indicate changes in cognitive function score by one year greater in GrimAA.