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. 2022 Feb 18;14(4):1797–1811. doi: 10.18632/aging.203903

Table 1. Basic characteristics of all qualified studies.

Study Region Cancer Sample size Gender Specimen Method Survival analysis Outcome Cut-off Follow-up (months) NOS
F M
Peng et al. 2014 China PC 304 136 168 tissue qRT-PCR Multivariate/Univariable OS mean 36 8
Yang et al. 2015 Korea HCC 240 tissue beadchip Multivariate/Univariable OS/DFS median 120 9
Li et al. 2015 China HCC 66 13 53 plasma qRT-PCR median 6
Li et al. 2016 China HCC 38 9 29 tissue qRT-PCR Kaplan-Meier curve OS mean 60 7
Jin et al. 2016 China GC 100 35 65 serum qRT-PCR Kaplan-Meier curve OS median 36 7
Yang et al. 2016 China CRC 35 tissue qRT-PCR Kaplan-Meier curve OS mean 120 6
Zhang et al. 2016 China GC 42 plasma qRT-PCR Kaplan-Meier curve OS mean 60 8
Sonohara et al. 2017 Japan HCC 158 26 132 tissue qRT-PCR Kaplan-Meier curve OS/RFS mean 120 8
Zhang et al. 2018 China CA 50 27 23 tissue qRT-PCR median 6
Dong et al. 2019 China CC 67 28 39 tissue qRT-PCR Kaplan-Meier curve OS mean 60 7
Oehme et al. 2019 Germany CRC 52 19 33 serum exosome qRT-PCR Kaplan-Meier curve OS median 100 6
Cao et al. 2019 China HCC 30 21 9 tissue, serum exosome qRT-PCR mean 6
Liu et al. 2020 China GC 116 40 76 tissue qRT-PCR median 7
Ou et al. 2020 China PC 60 17 43 serum qRT-PCR Multivariate/Univariable OS median 60 9

PC, pancreatic cancer; HCC, hepatocellular carcinoma; GC, gastric cancer; CRC, colorectal cancer; CC, colon cancer; CA, colon adenocarcinoma; F, female; M, male; OS, overall survival; DFS, disease-free survival; RFS, recurrence-free survival.