Table 2.
Cysteine residues in bacteria, yeast and human Hsp70 homologs.
| Hsp70 Homolog | Cysteine Residues (Entry in UniProtKB) |
|---|---|
| Escherichia coli DnaK | Cys15 (P0A6Y8) |
| Escherichia coli HscA (Hsc66) | Cys315, Cys448 (P0A6Z1) |
| Escherichia coli HscC (Hsc62) | Cys236, Cys242, Cys261, Cys344, Cys360 (P77319) |
| Saccharomyces cerevisiae Ssa1 (cytosol) | Cys15, Cys264, Cys303 (P10591) |
| Saccharomyces cerevisiae Ssa2 (cytosol) | Cys15, Cys264, Cys303 (P10592) |
| Saccharomyces cerevisiae Ssa3 (cytosol) | Cys15, Cys304 (P09435) |
| Saccharomyces cerevisiae Ssa4 (cytosol) | Cys15, Cys304 (P22202) |
| Saccharomyces cerevisiae Ssb1 (cytosol) | Cys20, Cys435, Cys454 (P11484) |
| Saccharomyces cerevisiae Ssb2 (cytosol) | Cys20, Cys454 (P40150) |
| Saccharomyces cerevisiae Sse1 (cytosol Hsp110) | Cys142, Cys211, Cys228, Cys380, Cys484 (P32589) |
| Saccharomyces cerevisiae Sse2 (cytosol Hsp110) | Cys142, Cys211, Cys380, Cys484 (P32590) |
| Saccharomyces cerevisiae Ssz1 (cytosol) | Cys81, Cys86 (P38788) |
| Saccharomyces cerevisiae Ssc1 (mitochondria) | None (P0CS90) |
| Saccharomyces cerevisiae Ssc2 (Ssq1) (mitochondria) | Cys134 (Q05931) |
| Saccharomyces cerevisiae Ssc3 (Ecm10) (mitochondria) | None (P39987) |
| Saccharomyces cerevisiae Ssd1 (Kar2, BiP, Grp78) (ER) | Cys63 (P16474) |
| Saccharomyces cerevisiae Lhs1 (Grp170) (ER) | Cys520, Cys545, Cys547 (P36016) |
| Human HspA1A (Hsp72) (cytosol, nucleus, cell membrane, extracellular exosomes) | Cys17, Cys267, Cys306, Cys574, Cys603 (P0DMV8) |
| Human HspA1B (Hsp72) (cytosol, nucleus, extracellular exosomes) | Cys17, Cys267, Cys306, Cys574, Cys603 (P0DMV9) |
| Human HspA1L (cytosol, nucleus) | Cys19, Cys269, Cys308, Cys576, Cys605, Cys617, Cys622 (P34931) |
| Human HspA2 (cytosol, nucleus, cell membrane, extracellular exosomes) | Cys18, Cys191, Cys270, Cys577, Cys606 (P54652) |
| Human HspA4 (Apg2) (cytosol, extracellular exosome, mitochondrion, nucleus) | Cys13, Cys34, Cys38, Cys140, Cys146, Cys167, Cys213, Cys245, Cys270, Cys290, Cys310, Cys376, Cys380, Cys417, Cys779 (P34932) |
| Human HspA4L (Apg1, Osp94) (cytosol, nucleus) | Cys13, Cys34, Cys38, Cys140, Cys167, Cys213, Cys245, Cys270, Cys290, Cys310, Cys376, Cys380, Cys417, Cys421, Cys540, Cys589, Cys740, Cys782 (O95757) |
| Human HspA5 (BiP, Grp78) (ER, extracellular exosomes) | Cys41, Cys420 (P11021) |
| Human HspA6 (Hsp70B’) (cytosol, extracellular exosomes) | Cys19, Cys108, Cys269, Cys308, Cys387, Cys576, Cys605, Cys624 (P17066) |
| Human HspA7 (Hsp70B) (blood microparticles, extracellular exosomes) | Cys19, Cys108, Cys269, Cys308 (P48741) |
| human HspA8 (Hsc70, Hsc73) (cytosol, nucleus, cell membrane, extracellular exosomes) | Cys17, Cys267, Cys574, Cys603 (P11142) |
| Human HspA9 (Grp75, mt-Hsp70) (mitochondria, nucleus) | Cys66, Cys317, Cys366, Cys487, Cys608 (P38646) |
| Human HspA12A (extracellular exosomes, nucleus) | Cys80, Cys246, Cys502, Cys564, Cys621 (O43301) |
| Human HspA12B (endothelial cells, intracellular, blood plasma) | Cys36, Cys106, Cys250, Cys321, Cys365, Cys450, Cys570, Cys595, Cys610, Cys611, Cys626, Cys639 (Q96MM6) |
| Human HspA13 (Stch) (ER, extracellular exosomes, microsomes) | Cys43 (P48723) |
| Human HspA14 (Hsp60, Hsp70L1) (cytosol, membrane) | Cys10, Cys14, Cys89, Cys280, Cys293, Cys304, Cys311, Cys335, Cys394, Cys440, Cys492, Cys500 (Q0VDF9) |
| Human HspH1 (Hsp105, Hsp110) (microtubule, cytosol, extracellular region or secreted, nucleus) | Cys13, Cys34, Cys48, Cys140, Cys167, Cys213, Cys245, Cys270, Cys290, Cys310, Cys376, Cys380, Cys516, Cys650, Cys658, Cys796, Cys845 (Q92598) |
| Human Hyou1 (Grp170, Orp150) (ER, extracellular region or secreted) | Cys15, Cys240, Cys352, Cys805 (Q9Y4L1) |