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Proprotein convertases (PCs) activity repression and CSC gene expression in colon CSCs. Effect of the PCs inhibitor α1-PDX expression on the expression of LGR5 (a,b), NANOG (c,d), OCT4 (e,f) and SOX2 (g,h) in the indicated parental colon cancer cells and their corresponding CSCs was assessed by real-time PCR analysis. Results are representative of three experiments and data are mean ± S.E.M performed in triplicate. * p < 0.05. NS: not significant.
