. 2022 Feb 24;14(5):1173. doi: 10.3390/cancers14051173

Table 5.

Univariate analysis of median overall survival based on main pre-infection clinical and laboratory parameters in unvaccinated hematological patients with COVID-19.

Clinical and Laboratory Parameters		N	mOS	95% CI	p-Value ^a
Age, years	≤70	35	11.9	12.2–14.5	0.33
Age, years	>70	51	10.8	9.8–13.5	0.33
Sex	Male	43	11.8	11.2–14.3	0.91
Sex	Female	43	11.4	11.1–13.8	0.91
Disease activity	Inactive	59	11.1	10.3–11.8	*0.003*
Disease activity	Active or progressing	27	8.5	6.4–10.7	*0.003*
Hematological malignancy	Myeloid	29	11.0	9.6–12.3	0.79
	Lymphoid	21	10.1	8.5–11.6
	Plasma cell	36	10.4	9.2–11.7
ANC, ×10³ cells/uL	≤4.0	60	9.9	8.8–11.0	0.06
ANC, ×10³ cells/uL	>4.0	26	11.6	10.8–11.3	0.06
ALC, ×10³ cells/uL	≤1.0	40	6.7	5.8–7.6	0.27
ALC, ×10³ cells/uL	>1.0	46	10.8	9.9–11.8	0.27
AMC, ×10³ cells/uL	≤0.4	43	9.6	8.3–11.0	*0.03*
AMC, ×10³ cells/uL	>0.4	43	11.1	10.3–12.0	*0.03*
Pre-infection LDH	≤243 IU/L	63	10.7	9.8–11.6	0.31
Pre-infection LDH	>243 IU/L	25	9.8	8.2–11.5	0.31
Pre-infection C-RP	≤5 IU/L	62	10.7	9.8–11.6	0.31
Pre-infection C-RP	>5 IU/L	24	5.8	4.8–6.8	0.31
Hospitalization for COVID-19	No	64	11.4	10.9–12.0	*<0.0001*
	Yes	22	7.6	5.5–9.8	*<0.0001*
Viral clearance at 14 days	No	47	11.2	10.5–11.8	*0.005*
	Yes	39	8.4	6.2–10.6	*0.005*
Seroconversion *	No	24	6.5	5.3–7.7	*0.05*
(* evaluated in N = 66)	Yes	42	12.0	12.0	*0.05*

^a based on Kaplan–Meier plots, p-value was considered significant if <0.05 and indicated in bold italic. Abbreviations: ALC, absolute lymphocyte count; AMC, absolute monocyte count; ANC, absolute neutrophil count; uL, micro-liter; IU/L, international units per liter; LDH, lactate de-hydrogenase; C-RP, C-reactive protein. * is to highlight that only 66 patients were evaluated for seroconversion.