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Hierarchical clustering of differentially expressed genes revealed a sexually dimorphic osteogenic regulator profile between male and female NCSCs undergoing differentiation. (A,B) Cluster of upregulated genes in male NCSCs comprising autosomal osteogenic regulator CYP7B1 as well as the Y-linked genes KDM5D and USP9Y. (C,D). Female NCSCs showed a cluster of upregulated genes including the pro-osteogenic regulators KDM6A and XIST as well as the negative regulator TXLNG.
