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. 2022 Feb 26;11(5):823. doi: 10.3390/cells11050823

Figure 6.

Figure 6

Pharmacological inhibition of KDM5D significantly reduced the capability of male NCSCs to undergo osteogenic differentiation. (A,B) Exposure of male NCSCs to increasing concentrations (1 µM–100 µM) of KDOAM-25 resulted in a significant reduction in calcium deposition after 30 days of differentiation compared to untreated control. (C) Quantification of Alizarin Red S confirmed the significant inhibition of male osteogenic differentiation upon inhibition of KDM5D by KDOAM-25-treatment. Mann–Whitney test, * p < 0.05 was considered significant. n.d.: not detectable.