Table 2.

CAR T cell and CAR T cell-derived EV. A comparison.

Event	CAR T Cells	CAR T Cell-Derived EV
Cytokine releasing syndrome	++	−
Neurotoxicity	++	−
Cross the blood barrier	−	++
Efficiency against solid tumors	+/−	++
Immunosuppression by tumoral PD-L1	+	−
Immunological memory	+ 1	(?) 2

¹ Depends on the use of central memory or effector memory CAR T cells. ² Not formally established.