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. 2022 Feb 26;14(5):1217. doi: 10.3390/cancers14051217

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Representative maximum intensity projection PET-CT images showing [¹⁸F]AlF-NOTA-KCNA3P tumour retention in αPD-1 responders, combined αPD1 + αCTLA4 responders and TNRs. Yellow dashed line indicates tumour boundary. (B) [¹⁸F]AlF-NOTA-KCNA3P tumour uptake values in each treatment arm; Control, αPD-1 responders and combined αPD1 + αCTLA4 responders compared to treated non-responsive tumours (TNR, n = 10–12 mice/ group; ** p < 0.01, **** p < 0.0001 comparing to TNR; data shown as the mean %ID/g ± S.E.M.). (C) [¹⁸F]AlF-NOTA-KCNA3P tumour uptake in CT26 TRs and TNRs (**** p < 0.0001, data shown as individual %ID/g).