Table 2.

EV-miRNA as a drug delivery system in HNSCC.

EV-miRNA	Loading Method	Donor Cell	Recipient Cell	EVs Isolation Method	miRNA Detection Method	Target	Effect	Ref.
miR-138	Lentiviral infection	γδ T cell	OSCC	Ultracentrifugation and precipitation	qRT-PCR	CTLA-4 and PD-1	Inhibition of cell proliferation and tumor growth	[109]
miR-185	miRNA-transfection	MSCs	OPMDs	Magnetic beads capturing	Microarray and qRT-PCR	AKT	Inhibition of inflammation and induction of apoptosis	[110]

Abbreviations: CTLA-4, cytotoxic T-lymphocyte-associated antigen 4; MSC, mesenchymal stromal cell; OPMD, oral potentially malignant disorders; OSCC, oral squamous cell carcinoma; PD-1, programmed cell death 1.