Table 1.
Structure | Name | Specificity | Inhibition Mechanism |
---|---|---|---|
Staurosporine | Pan-PKCs | competitive interfere with the ATP binding site | |
Midostaurin (PKC412, CGP41251, N-benzoylstaurosporine) |
cPKCs, nPKCs | competitive interfere with the ATP binding site | |
7-Hydroxystaurosporine (UCN-01) | cPKCs, nPKCs | competitive interfere with the ATP binding site | |
Sotrastaurin (AEB071) |
PKCα, β, θ, δ | competitive interfere with the ATP binding site | |
Enzastaurin (LY317615) |
PKCβ | competitive interfere with the ATP binding site | |
Bryostatin 1 | PKCα, PKCε, and PKCη | competitive interfere with the phorbol ester binding site |