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. 2022 Feb 22;14(5):1104. doi: 10.3390/cancers14051104

Table 1.

Inhibitors of PKC isoforms.

Structure Name Specificity Inhibition Mechanism
graphic file with name cancers-14-01104-i001.jpg Staurosporine Pan-PKCs competitive interfere with the ATP binding site
graphic file with name cancers-14-01104-i002.jpg Midostaurin
(PKC412, CGP41251, N-benzoylstaurosporine)		 cPKCs, nPKCs competitive interfere with the ATP binding site
graphic file with name cancers-14-01104-i003.jpg 7-Hydroxystaurosporine (UCN-01) cPKCs, nPKCs competitive interfere with the ATP binding site
graphic file with name cancers-14-01104-i004.jpg Sotrastaurin
(AEB071)		 PKCα, β, θ, δ competitive interfere with the ATP binding site
graphic file with name cancers-14-01104-i005.jpg Enzastaurin
(LY317615)		 PKCβ competitive interfere with the ATP binding site
graphic file with name cancers-14-01104-i006.jpg Bryostatin 1 PKCα, PKCε, and PKCη competitive interfere with the phorbol ester binding site