Table 4.
Additional molecular alteration in cutaneous metastases not found in primary tumors of paired cases.
| Location | Surrogated Molecular Type | Gene | Cases with Additional Mutation in Cutaneous Metastasis n |
|---|---|---|---|
| Distant cutaneous metastasis n = 17 |
TN | PIK3CA | 1 |
| RB1 | 1 | ||
| FGFR2 + MYC (amplification) | 1 | ||
| CTNNB1 | 1 | ||
| MDM4 (amplification) | 1 | ||
| Luminal HER2- | FGFR1 + NF1 | 1 | |
| BRCA2 + MKI67 + SF3B1 | 1 | ||
| CASP8 + ERBB2 | 1 | ||
| MDM4 (amplification) | 1 | ||
| HER2+ | KRAS + CCND1 (amplification) + MDM4 (amplification) | 1 | |
| BRCA1 + FGFR1 (polysomy) | 1 | ||
| Local cutaneous metastasis n = 15 |
TN | TP53 + PIK3CA + COL1A1 | 1 |
| PIK3CA | 1 | ||
| MYC (amplification) | 1 | ||
| Luminal HER2- | ERBB2 (polysomy) | 1 | |
| HER2+ | MYC (amplification) | 1 |
When not specified as an amplification, the alteration detected was a mutation.