Figure 3.

Prediction z-scores of NASH-specific upstream inflammatory regulators, canonical pathways, and inflammatory functions in hepatic in vitro NASH models exposed to elafibranor show a similar modulation to liver samples of patients with resolved NAFLD by bariatric surgery. Microarray analysis of upstream inflammatory mediators and Toll-like receptors (A), canonical pathways (B), and inflammatory functions (C) in PHH, HepaRG, and hSKP-HPC cultures exposed to ‘NASH’ triggers in the presence or absence of elafibranor is compared to data sets from NASH patients and NASH patients that underwent bariatric surgery [z-score of ≥2 indicates a significant activation; z-score of ≤−2 indicates a significant inhibition; grey fields indicate no available z-score].