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. 2022 Mar 4;11(5):893. doi: 10.3390/cells11050893

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Elafibranor-mediated upregulation of ANGPTL4, PDK4, and PLIN2 is predicted to induce steatosis functions in in vitro NASH models, contrarily to observed downregulation in patients with resolved NASH due to bariatric surgery. (A) Regulation of steatosis- and inflammation-related functions by PLIN2, ANGPTL4, and PDK4 in PHH, HepaRG, and hSKP-HPC cultures exposed to ‘NASH’ triggers and elafibranor. (B) Differential expression of ANGPTL4, PDK4, and PLIN2 in liver tissue from obesity/NAFLD patients that underwent bariatric surgery.