TABLE 1.
Frequencies of appearance of mutant strains by selection with various quinolones
| Selecting quinolone | Frequency at the following multiple of the MICa:
|
||||
|---|---|---|---|---|---|
| 2× | 4× | 8× | 16× | 32× | |
| Gatifloxacin | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 |
| Sparfloxacin | >2.2 × 10−6 | >2.2 × 10−6 | >2.2 × 10−6 | 1.1 × 10−7 | <1.1 × 10−9 |
| Trovafloxacin | >2.2 × 10−6 | 6.2 × 10−8 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 |
| Levofloxacin | 1.5 × 10−7 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 |
| Ciprofloxacin | >2.2 × 10−6 | 1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 |
| Norfloxacin | 2.6 × 10−7 | 2.2 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 | <1.1 × 10−9 |
a
The reproducibilities of the frequencies have been confirmed in repeated experiments.