TABLE 2.
Comparison of clinical and laboratory results for both preparations (n=29)
| Colchicum Dispert | Colchicine Opocalcium | p | |
|---|---|---|---|
| Duration of treatment (months) | 59.54±36.43 | 26.39±16.64 | <0.001 |
| Dose (mg/day) | 1.49±0.41 | 1.71±0.44 | <0.001 |
| Number of attacks at the last 6 months | 4.83±2.1 | 1.89±1.50 | <0.001 |
| Average duration of FMF attacks (hours) | 63.98±25.84 | 44.41±21.81 | <0.001 |
| EILP (attack-free period) | 7.36±1.43 | 2.84±1.77 | <0.001 |
| FMF severity score | 8.88±2.08 | 6.52±1.83 | <0.001 |
| Bristol stool scale | 5.62±1.56 | 4.15±1.73 | 0.044 |
| Number of stools/24 h | 0.46±0.894 | 0.03±0.118 | <0.001 |
| Hb (g/dL) | 12.40±0.26 | 12.75±0.76 | 0.062 |
| WBC (/mm3) | 7.654±2.290 | 7.672±2.207 | 0.958 |
| Plt (103/mm3) | 287±74 | 293 ± 46 | 0.385 |
| NLR (Neu/Lym) | 2.43±1.72 | 1.67±0.85 | 0.01 |
| MPV (fL) | 7.99±1.56 | 8.19±1.06 | 0.224 |
| ALT (U/L) | 19.94±11.82 | 24.61±12.83 | <0.001 |
| CRP (mg/L) | 0.95 (0.65–3.00) * | 0.66 (0.03–2.10) * | 0.044 |
| ESR (mm/h) | 27.07±13.03 | 19.11±9.20 | <0.001 |
*
Mean±standard deviation
**
Median (25th to 75th percentile)
ALT: Alanine Aminotransferase, CRP: C-Reactive Protein, EILP: Exercise-Induced Leg Pain (Visual Analog Scale Score), ESR: Erythrocyte Sedimentation Rate, FMF: Familial Mediterranean Fever, Hb: Hemoglobin, MPV: Mean Platelet Volume, NLR: Neutrophil-to-Lymphocyte Ratio, Plt: Platelet Count, WBC: White Blood Cell Count.
Number of stool/24 hours: 0–2: 0 point, 3–5: 1 point, 5–8: 2 points, >8: 3 points